Effect of Hyperbaric Oxygen Therapy on Insulin Resistance in PostMenopausal Women: A Randomized Assessor-Blinded Controlled Trial

Abstract

Background: In postmenopausal females, Insulin resistance is commonly
encountered in clinical setting. Hyperbaric oxygen therapy has been proposed
effective in lowering blood glucose level and improving function.
Identification of clinical examination variables as predictors to blood glucose
levels and dysfunction would offer therapists the chance to undertake clinical
decisions and consequently improve treatment efficiency. Objectives: to
examine the effect of hyperbaric oxygen therapy on insulin resistance in
postmenopausal women. Patients and methods: This Predictive validity,
diagnostic study included fourty postmenopausal participants with insulin
resistance recruited from Kobry el Koba Military Complex with age 55-65
years, Their BMI was 30-34.9 kg/m. They were equally divided randomly into:
group (A) who received Hyperbaric Oxygen therapy 5sessions per week for
30 consecutive sessions in addition to their oral hypoglycemic drugs. Group
(B) who received their oral hypoglycemic drugs only. Participants in group(A)
were assessed for fasting blood glucose level by glucometer, ACCU-Chek
performa, before treatment and post the 1st 10 sessions and post the 2nd 10
sessions while both groups were assessed for HgA1C level by blood sample ,
Health related quality of life by Quality of life enjoyment and satisfaction
questionnaire QLES-QSF pre- and post-treatment sessions. Results: Posttreatment, both groups showed a significant decrease in HbA1c levels and an
increase in QLES-QSFB, Group A showed a significantly greater decrease in
HbA1c levels and a significantly greater increase in QLES-QSFB compared
to group B (p<0.001). In group A,after both 10 and 30 sessions, there was a
significant decrease in fasting blood glucose (FBG)levels compared to pretreatment levels (p<0.001).Additionally ,FBG levels significantly decreased
after 30 sessions compared to after 10 sessions (p<0.001). Conclusion:
Hyperbaric oxygen therapy was effective in managing insulin resistance in
postmenopausal women.