Exploring the Efficacy of Perioperative Magnesium Sulfate in Preventing Postoperative Acute Pain and Reducing Analgesic Requirements

Abstract

Magnesium sulfate has gained attention as a potential adjunct in perioperative analgesia due to its proposed ability to modulate pain pathways and reduce opioid consumption. This randomized controlled trial investigates the efficacy of perioperative magnesium sulfate administration in patients undergoing major orthopedic surgery. We evaluated its effects on postoperative acute pain, opioid consumption, and the incidence of side effects such as nausea and sedation. Patients receiving magnesium sulfate showed significantly reduced pain scores within the first 24 hours post-surgery and required lower doses of opioids compared to the placebo group. Additionally, the incidence of postoperative nausea and vomiting was lower in the magnesium group, suggesting a potential benefit in reducing opioid-related side effects. These findings support the incorporation of magnesium sulfate into multimodal analgesia regimens to improve patient outcomes and enhance recovery.