CLINICO-MICROBIOLOGICAL PROFILE OF CENTRAL LINE ASSOCIATED BLOOD STREAM INFECTION (CLABSI) AND ASSOCIATED RISK FACTORS AMONG PATIENTS ADMITTED IN A TERTIARY CARE HOSPITAL, NAVIMUMBAI

Abstract

Background – Central line-associated bloodstream infection is an infection that
occurs when microorganisms enter bloodstream through central line that occurs
within 48 hours of central line placement. This study undertaken to determine
clinico-microbiological profile, antimicrobial susceptibility pattern and risk
factors associated with CLABSI.
Methods – This is a descriptive and Prospective Study from January to
December 2022, under aseptic conditions 30 IPD patients' blood were cultured
manually and a catheter tip culture were cultured using the semi-quantitative
roll-plate and quantitative vortex method. Kirby-Bauer disk diffusion method
used to study Antibiotic susceptibility profiles. All the results were statistically
analysed by using Crude Odds Ratio and P value.
Result- out of 30 samples, 18 (60%) were CLABSI positive. The majority of
CLABSI patients were in ICU (83%) and highly prevalent over the age of 50
(61%) and in men (66%).CLABSI rate in our study period was determined to
be 2.73 (1.58 - 4.50) per 1000 catheter days. Gram Negative Bacteria (61%)
were found to be higher in prevalence than Gram Positive (39%) Bacteria, with
Enterobacter (36%) being with greatest incidence among GNB and S. aureus
(43%) among GPC. variant and Independent risk variables were also
investigated.
Conclusion- According to this study, high risk variables related with CLABSI
were identified, and more MDR organisms were isolated. To reduce this, it is
essential to follow proper antibiotic policies, central line insertion and
maintenance bundles.