Diagnostic value of laboratory techniques in diagnosing Drug-Induced Lupus erythematosus among long-standing tuberculosis patients on treatment with Isoniazid

Abstract

Background: Drug-induced lupus erythematosus (DILE) is a variant of lupus
erythematosus that resolves within days to months after withdrawal of the
culprit drug in a patient with no underlying immune system dysfunction. The
etiology of these presentations presents as a diagnostic dilemma to the
physician. Moreover, no existing literature could be found that studied the
comparative antibody profiles of patientsdeveloping rash due to DILE and those
developing rash due to other aetiologies. So, the differentiation was done based
on the antibody profiles that are essential to help physicians. Methods: By
stratified random sampling, the 11 study population was introduced into the
study that had been diagnosed with having DLE and rash persists even after
discontinuation of ATT. Thereafter, all of the patients persons were subjected
to the estimation of serum ANA, anti-histone antibody, anti-dsDNA antibody
and anti-ssDNA antibody, and find out C3 and C4 concentration. Results: it
was found that among 95% patients have positive anti-histone antibody and
near about 90% have antinuclear antibodies. Almost all patients were positive
for anti-ssDNA. But anti-dsDNA was rare and serum concentration of C3 and
C4 were normal. Conclusion: Serological profile of INH induced DIL in the
study, it was found that among 95% patients have positive anti-histone antibody
and 90% have antinuclear antibodies. Almost all patients were positive for antissDNA. But anti-dsDNA was rare and serum concentration of C3 and C4 were
normal.